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Unexpected features of the dark proteome

2015; National Academy of Sciences; Volume: 112; Issue: 52 Linguagem: Inglês

10.1073/pnas.1508380112

1091-6490

Nelson Perdigão, Julian Heinrich, Christian Stolte, Kenneth S. Sabir, Michael Buckley, Bruce Tabor, Beth Signal, Brian Gloss, Christopher Hammang, Burkhard Rost, Andrea Schafferhans, Séan O’Donoghue,

Protein Structure and Dynamics

Significance A key remaining frontier in our understanding of biological systems is the “dark proteome”—that is, the regions of proteins where molecular conformation is completely unknown. We systematically surveyed these regions, finding that nearly half of the proteome in eukaryotes is dark and that, surprisingly, most of the darkness cannot be accounted for. We also found that the dark proteome has unexpected features, including an association with secretory tissues, disulfide bonding, low evolutionary conservation, and very few known interactions with other proteins. This work will help future research shed light on the remaining dark proteome, thus revealing molecular processes of life that are currently unknown.