Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety
2006; Elsevier BV; Volume: 16; Issue: 13 Linguagem: Inglês
10.1016/j.bmcl.2006.03.103
ISSN1464-3405
AutoresAlireza Foroumadi, Shahram Ghodsi, Saeed Emami, S. Najjari, Nasrin Samadi, Mohammad Ali Faramarzi, Leila Beikmohammadi, Farshad H. Shirazi, Abbas Shafiee,
Tópico(s)Antibiotic Resistance in Bacteria
ResumoN-(Phenethyl)piperazinyl quinolone derivatives that bear a methoxyimino-substituent have been synthesized and evaluated for antimicrobial activity against Gram-positive and Gram-negative microorganisms. In addition, to define structure-activity relationships, ciprofloxacin derivatives containing 2-oxo-2-phenylethyl or 2-hydroxyimino-2-phenylethyl moieties at N-4 position of piperazine ring were prepared and tested. Ciprofloxacin derivatives, containing a N-(chloro-substituted phenethyl) residue, showed in vitro Gram-positive and Gram-negative activity generally comparable or superior to that of reference quinolones.
Referência(s)