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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Teicoplanin inhibits Ebola pseudovirus infection in cell culture

2015; Elsevier BV; Volume: 125; Linguagem: Inglês

10.1016/j.antiviral.2015.11.003

ISSN

1872-9096

Autores

Yizhuo Wang, Rui Cui, Guiming Li, Qianqian Gao, Shilin Yuan, Ralf Altmeyer, Gang Zou,

Tópico(s)

Viral gastroenteritis research and epidemiology

Resumo

There is currently no approved antiviral therapy for treatment of Ebola virus disease. To discover readily available approved drugs that can be rapidly repurposed for treatment of Ebola virus infections, we screened 1280 FDA-approved drugs and identified glycopeptide antibiotic teicoplanin inhibiting Ebola pseudovirus infection by blocking virus entry in the low micromolar range. Teicoplanin could be evaluated further and incorporated into ongoing clinical studies.

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