Produção Nacional
Revisado por pares
Icodextrin reduces insulin resistance in non-diabetic patients undergoing automated peritoneal dialysis: results of a randomized controlled trial (STARCH)
2015; Oxford University Press; Volume: 30; Issue: 11 Linguagem: Inglês
10.1093/ndt/gfv247
ISSN1460-2385
AutoresThyago Proença de Moraes, Maria Cláudia Cruz Andreoli, María Eugênia Fernandes Canziani, Dirceu Reis da Silva, Jacqueline Costa Teixeira Caramori, Daniela Ponce, Hélio Vida Cassi, Kleyton de Andrade Bastos, Danyelle Romana Alves Rio, Sérgio Wyton Lima Pinto, Sebastião Rodrigues Ferreira Filho, Ludimila Guedim de Campos, Márcia Olandoski, José Carolino Divino‐Filho, Roberto Pécoits-Filho,
Tópico(s)Pharmacological Effects and Toxicity Studies
ResumoInsulin resistance is a common risk factor in chronic kidney disease patients contributing to the high cardiovascular burden, even in the absence of diabetes. Glucose-based peritoneal dialysis (PD) solutions are thought to intensify insulin resistance due to the continuous glucose absorption from the peritoneal cavity. The aim of our study was to analyse the effect of the substitution of glucose for icodextrin on insulin resistance in non-diabetic PD patients in a multicentric randomized clinical trial. This was a multicenter, open-label study with balanced randomization (1:1) and two parallel-groups. Inclusion criteria were non-diabetic adult patients on automated peritoneal dialysis (APD) for at least 3 months on therapy prior to randomization. Patients assigned to the intervention group were treated with 2L of icodextrin 7.5%, and the control group with glucose 2.5% during the long dwell and, at night in the cycler, with a prescription of standard glucose-based PD solution only in both groups. The primary end-point was the change in insulin resistance measured by homeostatic model assessment (HOMA) index at 90 days. Sixty patients were included in the intervention (n = 33) or the control (n = 27) groups. There was no difference between groups at baseline. After adjustment for pre-intervention HOMA index levels, the group treated with icodextrin had the lower post-intervention levels at 90 days in both intention to treat [1.49 (95% CI: 1.23–1.74) versus 1.89 (95% CI: 1.62-2.17)], (F = 4.643, P = 0.03, partial η2 = 0.078); and the treated analysis [1.47 (95% CI: 1.01–1.84) versus 2.18 (95% CI: 1.81–2.55)], (F = 7.488, P = 0.01, partial η2 = 0.195). The substitution of glucose for icodextrin for the long dwell improved insulin resistance measured by HOMA index in non-diabetic APD patients.
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