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Malignant Lymphoma in Survivors of the Atomic Bomb in Hiroshima

1964; American College of Physicians; Volume: 61; Issue: 5_Part_1 Linguagem: Inglês

10.7326/0003-4819-61-5-853

1539-3704

Robert E. Anderson,

Radiation Dose and Imaging

Article1 November 1964Malignant Lymphoma in Survivors of the Atomic Bomb in HiroshimaROBERT E. ANDERSON, M.D., KENZO ISHIDA, M.D.ROBERT E. ANDERSON, M.D.Search for more papers by this author, KENZO ISHIDA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-5-853 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA causal relation between leukemia and ionizing radiation has been well documented in both man and laboratory animals (1-4). Similarly, there is an increased frequency of myelofibrosis with myeloid metaplasia in survivors of the atomic bomb in Hiroshima (5). Since a close relationship between the myeloproliferative disorders and malignant lymphomas is now generally accepted, the occurrence of the malignant lymphomas might be expected to be increased in survivors of the atomic bomb.This report concerns the prevalence of Hodgkin's disease, lymphosarcoma, reticulum cell sarcoma, and multiple myeloma in the surgical and autopsy material examined at the Atomic Bomb Casualty Commission...References1. COURT-BROWNDOLL WMR: Leukemia and aplastic anemia in patients irradiated for ankylosing spondylitis. Medical Research Council Special Report Series, No. 295. Her Majesty's Stationery Office, London, 1957. Google Scholar2. MARTLAND HS: The occurrence of malignancy in radioactive persons. Amer. J. Cancer 15: 2435, 1931. Google Scholar3. HEYSSELBRILLWOODBURYNISHIMURAGHOSEHOSHINOYAMASAKI RABLAETTTM: Leukemia in Hiroshima atomic bomb survivors. Blood 15: 313, 1960. CrossrefMedlineGoogle Scholar4. FURTHUPTONKIMBALL JACAW: Late pathologic effects of atomic detonation and their pathogenesis. Radiat. Res. (supplement) 1: 243, 1959. Google Scholar5. ANDERSONHOSHINOYAMAMOTO RETT: Myelofibrosis with myeloid metaplasia in survivors of the atomic bomb in Hiroshima. Ann. Intern. Med. 60: 1, 1964. LinkGoogle Scholar6. ARAKAWA ET: Radiation dosimetry in Hiroshima and Nagasaki atomic bomb survivors. ABCC TR 14-59. Google Scholar7. STONEANDERSON RSPS: Epidemiologic evaluation of ABCC autopsies, Hiroshima 1950-59. ABCC TR 22-60. Google Scholar8. ZELDISMATSUMOTO LS: Research plan for joint ABCC-NIH pathology studies in Hiroshima and Nagasaki. ABCC TR 12-62. Google Scholar9. TSUZURA T: Statistical observation on autopsy cases of tumors in Eastern Japan during ten year period from 1946 to 1955 inclusive. Iryo 13: 79, 1959. Google Scholar10. MIYAJIYUHODAISHIDATSUZURA THTKT: The incidence of malignant tumors in autopsy cases of Japan during the ten years from 1946 to 1955 inclusive. Gann 48: 523, 1957. MedlineGoogle Scholar11. NISHIO S: A statistical and histological study of malignant lymphoma in Japan based on autopsy and biopsy cases. Osaka City Med. J. 11: 317, 1959. Google Scholar12. JABLONISHIDAYAMASAKI SMM: JNIH-ABCC life span study: report 3. Mortality from October 1950 to September 1960. ABCC TR 15-63 (in press). Google Scholar13. SOCOLOWHASHIZUMENERIISHINIITANI ELASR: Thyroid carcinoma in man after exposure to ionizing radiation. New Eng. J. Med. 268: 406, 1963. CrossrefMedlineGoogle Scholar14. GROSS L: Viral etiology of "spontaneous" mouse leukemia: A review. Cancer Res. 18: 371, 1958. MedlineGoogle Scholar15. LAMSONBILLINGSBENNETT BGMSLR: Neoplasms and other diseases in aging rats following partial- or total-body X-irradiation. Arch. Path. (Chicago) 67: 471, 1959. MedlineGoogle Scholar16. BLAIR HA (editor): Biological Effects of External Radiation, McGraw-Hill Book Company Inc., New York, 1954. Google Scholar17. FINERTYBINHAMMERSCHNEIDERCUNNINGHAM JCRTMAW: Neoplasms in rats exposed to a single-dose total-body X radiation. J. Nat. Cancer Inst. 14: 149, 1953. MedlineGoogle Scholar18. ANGEVINEJABLONMATSUMOTO DMSS: ABCC-JNIH pathology studies, report 1: October 1950-September 1962. ABCC TR 14-63 (in press). Google Scholar19. KAPLAN HS: Observations on radiation-induced lymphoid tumors of mice. Cancer Res. 7: 141, 1947. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT E. ANDERSON, M.D.; KENZO ISHIDA, M.D.Affiliations: Hiroshima, JapanFrom the Department of Pathology, Atomic Bomb Casualty Commission, Hiroshima, Japan. (A research agency of the U. S. National Academy of Sciences-National Research Council under a grant from the U. S. Atomic Energy Commission administered in cooperation with the Japanese National Institute of Health of the Ministry of Health and Welfare.)Requests for reprints should be addressed to Robert E. Anderson, M.D., Atomic Bomb Casualty Commission, Hijiyama Park, Hiroshima, Japan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIonizing Radiation and Tumor ProductionCancer following cardiac catheterization in childhoodMaligne SystemerkrankungenLeukemia, Multiple Myeloma, and Malignant LymphomaLate effects of use of nuclear and certain chemical weapons in manÄtiologie und Pathogenese der Non-Hodgkin-LymphomeCancer of the head and neck in atomic bomb survivors: Hiroshima and Nagasaki, 1957–1976Radiation-induced leukemias in ankylosing spondylitisMultiple myelomaChronic exposure to benzene as a possible contributary etiologic factor in Hodgkin's diseaseDie LymphogranulomatoseCancer and Leukemia Developing among Atom-Bomb SurvivorsThe incidence of malignant lymphoma and multiple myeloma in Hiroshima and Nagasaki atomic bomb survivors, 1945–1965Late clinical and roentgen observations following thorotrast administrationPATHOGENESIS OF RADIATION-RELATED LEUKÆMIA AND LYMPHOMAFrequency of induction of malignancies in man by ionising radiationMalignant lymphomaOther tumorsIonizing radiation and man: the biological hazardsThe relative sensitivity of different tissues to tumour induction by radiation: The human evidenceINDUCTION OF LYMPHOMA AND LEUKEMIA BY DIAGNOSTIC AND THERAPEUTIC IRRADIATIONSchäden durch strahlende EnergieThe Treatment of Plasma Cell Myeloma 1 November 1964Volume 61, Issue 5_Part_1Page: 853-862KeywordsEpidemiologyHodgkin lymphomaIonizing radiationLymphocytic leukemiaLymphomaMultiple myelomaMyeloproliferative disordersNeutrophilsResearch laboratoriesSarcoma ePublished: 1 December 2008 Issue Published: 1 November 1964 PDF downloadLoading ...