An azetidinium ion approach to 3-aryloxy-3-aryl-1-propanamines
2002; Elsevier BV; Volume: 43; Issue: 41 Linguagem: Inglês
10.1016/s0040-4039(02)01724-0
ISSN1873-3581
AutoresPeter O’Brien, David Phillips, Timothy D. Towers,
Tópico(s)Phenothiazines and Benzothiazines Synthesis and Activities
ResumoTreatment of 3-(dimethylamino)-1-phenyl-propan-1-ol with mesyl chloride and then different phenols generates a range of N,N-dimethyl-3-aryloxy-3-aryl-1-propanamines via regiospecific opening of a proposed azetidinium ion intermediate. During the rearrangement process, there was some leakage of stereochemical integrity.
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