Application of the Dakin−West Reaction for the Synthesis of Oxazole-Containing Dual PPARα/γ Agonists
2003; American Chemical Society; Volume: 68; Issue: 7 Linguagem: Inglês
10.1021/jo026655v
ISSN1520-6904
AutoresAlexander G. Godfrey, Dawn A. Brooks, Lynne A. Hay, Mary Peters, James R. McCarthy, David Mitchell,
Tópico(s)Click Chemistry and Applications
ResumoAn improved method for the preparation of a series of oxazole-containing dual PPARalpha/gamma agonists is described. A synthetic sequence utilizing a Dakin-West reaction was devised that allows for the introduction of the oxazole ring either late in the synthetic sequence via aminomalonate-derived chemistry or in pivotal SAR intermediates derived from aspartic acid.
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