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BIBTEX RIS

Salvinicins A and B, New Neoclerodane Diterpenes from Salvia d ivinorum

2005; American Chemical Society; Volume: 7; Issue: 14 Linguagem: Inglês

10.1021/ol0510522

ISSN

1523-7060

Autores

Wayne W. Harding, Kevin Tidgewell, Matthew Schmidt, Kushal Shah, Christina M. Dersch, John P. Snyder, Damon A. Parrish, Jeffrey R. Deschamps, Richard B. Rothman, Thomas E. Prisinzano,

Tópico(s)

Receptor Mechanisms and Signaling

Resumo

[reaction: see text] Two new neoclerodane diterpenes, salvinicins A (4) and B (5), were isolated from the dried leaves of Salvia divinorum. The structures of these compounds were elucidated by spectroscopic techniques, including (1)H and (13)C NMR, NOESY, HMQC, and HMBC. The absolute stereochemistry of these compounds was assigned on the basis of single-crystal X-ray crystallographic analysis of salvinicin A (4) and a 3,4-dichlorobenzoate derivative of salvinorin B.

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