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Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B

2004; Elsevier BV; Volume: 15; Issue: 3 Linguagem: Inglês

10.1016/j.bmcl.2004.11.060

1464-3405

Song Feng, Yu Xia, Dongmei Han, Chunyan Zheng, Xuchang He, Xi-can Tang, Donglu Bai,

Chemical synthesis and alkaloids

By targeting dual active sites of AChE, a number of new derivatives of HupB have been synthesized and tested as acetylcholinesterase inhibitors. The most potent compound, bis-HupB 5b is 72-fold more potent in AChE inhibition and 79-fold more selective for AChE versus BChE than HupB.