Application of DMF–methyl sulfate adduct in the regioselective synthesis of 3-acylated indolizines
2007; Elsevier BV; Volume: 48; Issue: 33 Linguagem: Inglês
10.1016/j.tetlet.2007.06.095
ISSN1873-3581
AutoresTeresa Przewloka, Shoujun Chen, Zhiqiang Xia, Hao Li, Shijie Zhang, Dinesh Chimmanamada, E. I. KOSTIK, David A. James, Keizo Koya, Lijun Sun,
Tópico(s)Synthesis and Characterization of Pyrroles
ResumoA number of 3-acylated indolizines were synthesized in good to excellent yields by a newly established reaction between picolinium salts and the methylsulfate salt of A (R = Me), the adduct formed from DMF–Me2SO4 as the key reagent. The low cost, short reaction time, mild reaction condition, and easy purification of the products make this an attractive new method for the synthesis of indolizine compounds. A variety of functional groups (nitro, cyano, ester, methoxy, and halogens) were well tolerated under the reaction conditions.
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