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High-speed recording of neural spikes in awake mice and flies with a fluorescent voltage sensor

2015; American Association for the Advancement of Science; Volume: 350; Issue: 6266 Linguagem: Inglês

10.1126/science.aab0810

1095-9203

Yiyang Gong, Cheng Huang, Jin Zhong Li, Benjamin F. Grewe, Yanping Zhang, Stephan Eismann, Mark J. Schnitzer,

Neuroscience and Neural Engineering

In vivo imaging of neuronal voltage spikes Neuroscientists have long sought tools that allow optical imaging of individual neurons' membrane voltage dynamics in awake behaving animals. Gong et al. genetically engineered a protein voltage indicator that can report action potentials with <1-ms precision and orders of magnitude lower spike detection error rates than were previously possible. They were thus able to record action potentials and membrane voltage dynamics in the brains of awake mice and fruit flies. Science , this issue p. 1361