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Serum Thiol/Disulphide Homeostasis in Preeclampsia

2015; Informa; Volume: 34; Issue: 4 Linguagem: Inglês

10.3109/10641955.2015.1077859

1525-6065

Sibel Özler, Özcan Erel, Efser Öztaş, Ali Özgür Ersoy, Merve Ergin, Ayhan Sucak, Salim Neşeli̇oğlu, Dilek Şahın, Nuri Danışman,

Birth, Development, and Health

To determine the serum thiol/disulphide homeostasis in preeclampsia and to investigate the association with clinical parameters.Forty-three pregnant women with preeclampsia and 43 healthy, uncomplicated pregnancies were included in the study. Native thiol, disulphide, and total thiol concentrations were measured by a novel automated method.The serum native and total thiol levels were significantly lower in preeclampsia when compared with the healthy group (p < 0.001). There were significant correlations among the homeostatic parameters and preeclampsia.Serum thiol/disulphide homeostasis may have a role in the pathogenesis and can be evaluated with the clinical and laboratory findings of preeclampsia.