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Synthesis and QSAR studies of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives as potential antimicrobial agents

2004; Elsevier BV; Volume: 14; Issue: 16 Linguagem: Inglês

10.1016/j.bmcl.2004.06.014

1464-3405

Pratibha Sharma, Nilesh Rane, V. K. Gurram,

Synthesis and Characterization of Heterocyclic Compounds

A number of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives were synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds showed the potent antimicrobial activity. The quantitative structure-activity relationship investigation was applied to find a correlation between the different physicochemical parameters of the compounds studied and their biological activity.