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Shunt and ventilation-perfusion distribution during partial liquid ventilation in healthy piglets

1997; American Physiological Society; Volume: 82; Issue: 3 Linguagem: Inglês

10.1152/jappl.1997.82.3.933

8750-7587

Elisabeth Mates, J. Hildebrandt, J. Craig Jackson, Peter Tarczy‐Hornoch, Michael P. Hlastala,

Neuroscience of respiration and sleep

Mates, Elisabeth A., Jacob Hildebrandt, J. Craig Jackson, Peter Tarczy-Hornoch, and Michael P. Hlastala. Shunt and ventilation-perfusion distribution during partial liquid ventilation in healthy piglets. J. Appl. Physiol.82(3): 933–942, 1997.—Replacing gas in the lung with perfluorocarbon fluids (PFC) and periodically ventilating with a gas [partial liquid ventilation (PLV)] has been shown to improve oxygenation in models of respiratory distress syndrome. We hypothesized that the addition of PFC to healthy lungs would result in shunt, diffusion impairment, and increased ventilation-perfusion (V˙a/Q˙) heterogeneity. Previously, Mates et al. showed that O 2 shunt and arterial-alveolar CO 2 difference increased linearly with dose in piglets given graded intratracheal doses of PFC (10, 20, and 30 ml/kg followed by mechanical ventilation with 100% O 2 ) (E. A. Mates, J. C. Jackson, J. Hildebrandt, W. E. Truog, T. A. Standaert, and M. P. Hlastala. In: Oxygen Transport to Tissue XVI, 1994, p. 427–435). Here we reportV˙a/Q˙ distribution in the same animals, showing a 50% increase inV˙a/Q˙ heterogeneity during PLV independent of PFC dose. Ventilation heterogeneity was the major factor in this increase, and there was no significant change in dead space ventilation. We also report on five animals given a single 20 ml/kg dose of PFC and followed for 3 h. They showed an increase in shunt during PLV but no change in arterial-alveolar CO 2 difference.