Stereoselective synthesis of anti-1,3-diol units via Prins cyclisation: application to the synthesis of (−)-sedamine
2006; Elsevier BV; Volume: 47; Issue: 26 Linguagem: Inglês
10.1016/j.tetlet.2006.04.102
ISSN1873-3581
AutoresJ. S. Yadav, Maddi Sridhar Reddy, P. Purushothama Rao, A. R. Prasad,
Tópico(s)Marine Sponges and Natural Products
ResumoThe scope of the Prins cyclisation, the higher stereoselective synthesis of multisubstituted tetrahydropyrans from aldehydes and homoallylic alcohols, is expanded. A new approach for the stereoselective synthesis of polyketide precursors containing anti-1,3-diols, flanked by a variety of alkyl branches and functional groups is described. The approach is successfully exploited for the synthesis of (−)-sedamine.
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