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Artigo Revisado por pares
BIBTEX RIS

Design and synthesis of phosphotyrosine mimetics

2003; Elsevier BV; Volume: 13; Issue: 12 Linguagem: Inglês

10.1016/s0960-894x(03)00253-1

ISSN

1464-3405

Autores

Zheng Yan, Michaël Kahn, Maher Qabar, Ján Urban, Hwa-Ok Kim, Mark A. T. Blaskovich,

Tópico(s)

Protein Kinase Regulation and GTPase Signaling

Resumo

Selective inhibitors of protein tyrosine phosphatases (PTPases) are of great interest as therapeutic agents and research tools. Several phenylalanine derivatives (1, 2) designed as phosphotyrosine mimetics or irreversible active site inhibitors were successfully synthesized, then incorporated into a combinatorial library based on a peptidomimetic beta-strand template.

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