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Functional polymorphism rs710218 in the gene coding GLUT1 protein is associated with in-stent restenosis

2015; Future Medicine; Volume: 9; Issue: 8 Linguagem: Inglês

10.2217/bmm.15.36

1752-0371

Tadeusz Osadnik, Joanna Katarzyna Strzelczyk, Kamil Bujak, Rafał Reguła, Jarosław Wasilewski, Martyna Fronczek, Anna Kurek, Marcin Gawlita, Małgorzata Gonera, Marek Gierlotka, Andrzej Lekston, Michał Hawranek, Krzysztof Myrda, Andrzej Wiczkowski, Zofia Ostrowska, Mariusz Gąsior, Lech Poloński,

Cancer-related molecular mechanisms research

Aim: To analyze the association between in-stent restenosis (ISR) and polymorphisms in genes coding IGF-1, IGFBP3, ITGB3 and GLUT1, which play an important role in the smooth muscle cell proliferation and extracellular matrix synthesis – the main components of neointima. Materials & methods: We analyzed 265 patients who underwent bare metal stent implantation. Results: The differences in the occurrence of ISR between genotypes of the analyzed polymorphisms in the IGF-1, IGFBP3 and ITGB3 were not statistically significant. The T/T genotype of the rs710218 polymorphism in the GLUT1 (SLC2A1) gene was more common in the ISR group compared with non-ISR patients (81.1 vs 64.8%; p = 0.02). In a multivariable model the A/A and A/T genotype remained correlated with lower occurrence of ISR (odds ratio: 0.45; 95% CI: 0.21–0.97; p = 0.03). Conclusion: The rs710218 polymorphism in the gene coding GLUT1 protein is a novel risk factor for ISR.