Risks and benefits of sex-mismatched hematopoietic cell transplantation differ according to conditioning strategy
2015; Ferrata Storti Foundation; Volume: 100; Issue: 11 Linguagem: Inglês
10.3324/haematol.2015.125294
ISSN1592-8721
AutoresHideki Nakasone, Mats Remberger, Lü Tian, Petter Brodin, Bita Sahaf, Fang Wu, Jonas Mattsson, Robert Lowsky, RS Negrin, David B. Miklos, Everett Meyer,
Tópico(s)Immune Cell Function and Interaction
ResumoSex-mismatched hematopoietic cell transplantation is linked to increased graft-versus-host disease and mortality in myeloablative conditioning. Here we evaluated outcomes of 1,041 adult transplant recipients at two centers between 2006 and 2013 and investigated how the effect of sex-mismatching differed in myeloablative, reduced-intensity, and non-myeloablative total lymphoid irradiation with anti-thymocyte globulin conditioning. Among patients who underwent myeloablative conditioning, male recipients with female donors had increased chronic graft-versus-host disease (hazard ratio 1.83, P
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