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BIBTEX RIS

Induction of G2/M cell cycle arrest and apoptosis by a benz[f]indole-4,9-dione analog in cultured human lung (A549) cancer cells

2004; Elsevier BV; Volume: 14; Issue: 20 Linguagem: Inglês

10.1016/j.bmcl.2004.07.062

ISSN

1464-3405

Autores

Eunjin Lee, Hyunjung Lee, Hyen Joo Park, Hye‐Young Min, Myung‐Eun Suh, Hwa‐Jin Chung, Sang Kook Lee,

Tópico(s)

Synthesis and bioactivity of alkaloids

Resumo

A synthetic benz[f]indole-4,9-dione analog, 2-amino-3-ethoxycarbonyl-N-methylbenz[f]indole-4,9-dione (SME-6), showed a potent growth inhibition of a panel of human cancer cell lines. The mechanism of action study revealed that the growth inhibitory effect of SME-6 was highly related to the induction of G2/M cell cycle arrest and apoptosis in human lung cancer cells (A549). These data may provide new information for understanding the mechanisms by benz[f]indole-4,9-diones-mediated antitumor activity.

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