Immunogenicity of hepatitis B vaccine in oncology patients receiving chemotherapy.
1985; Lippincott Williams & Wilkins; Volume: 3; Issue: 5 Linguagem: Inglês
10.1200/jco.1985.3.5.718
ISSN1527-7755
AutoresAlan B. Weitberg, Sigmund A. Weitzman, E Watkins, Christine Hinkle, S O'Rourke, Jules L. Dienstag,
Tópico(s)Organ Transplantation Techniques and Outcomes
ResumoWe evaluated the immunogenicity and safety of three 40 micrograms doses of hepatitis B vaccine in oncology patients receiving chemotherapy. Of 76 patients screened for entry into the study, 13 (17%) already had been exposed to hepatitis B and were ineligible; 26 chose to join the study. The cumulative life-table response rate during the 12-month observation period was 70.8%; adequate immune response was linked to survival, 73% in survivors completing the study and 9% in nonsurvivors. Adverse effects were minor. We conclude that hepatitis B vaccine is safe and usually effective in inducing immunity in oncology patients younger than 60 years of age who are receiving chemotherapy.
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