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Mechanism of Action of Novel Marine Neurotoxins on Ion Channels

1988; Annual Reviews; Volume: 28; Issue: 1 Linguagem: Inglês

10.1146/annurev.pa.28.040188.001041

1545-4304

C H Wu, Toshio Narahashi,

Marine Toxins and Detection Methods

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism ...Read More