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BIBTEX RIS

Problems of variable biomarker evaluation in stratified medicine research—A case study of ERCC1 in non-small-cell lung cancer

2015; Elsevier BV; Volume: 92; Linguagem: Inglês

10.1016/j.lungcan.2015.11.017

ISSN

1872-8332

Autores

K Malottki, Sanjay Popat, Jonathan J Deeks, Richard D. Riley, Andrew G. Nicholson, Lucinda Billingham,

Tópico(s)

Genetic factors in colorectal cancer

Resumo

Consistency of procedures for the evaluation of a predictive biomarker (including sample collection, processing, assay and scoring system) based on adequate evidence is necessary to implement research findings in clinical practice. As a case study we evaluated how a particular predictive biomarker, ERCC1, was assessed in research on platinum-based chemotherapy in non-small-cell lung cancer and what motivated the choice of procedure.

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