Acute toxicity and antifungal studies of ethanolic leaves, stem and pulp extract of Tamarindus indica
2010; Volume: 1; Issue: 4 Linguagem: Inglês
ISSN
0975-8585
AutoresM. G. Abubakar, Mohammed Bello Yerima, A. G. Zahriya, A. N. Ukwuani,
Tópico(s)Hibiscus Plant Research Studies
ResumoThe acute oral toxicity studies of the pulp extract of Tamarindus indica at 3000mg/kg and 5000mg/kg body weight of resulted in no mortality. This suggests that the LD50 is greater than 5000mg/kg body weight and can be classified as practically non-toxic and considered safe by the recommendations of World Health Organization (WHO) and Organization for Economic and Cultural Development (OECD). Antifungal activity of ethanolic extract of Tamarindus indica (leaves, stem bark and pulp) against A. niger, A.flavus and F.oxysporum was studied. The result showed a dose dependent increase in inhibition of growth of these organisms. Of the three(3) plant part the stem bark did not inhibit growth of A. niger and slightly inhibited the growth of A.flavus and F.oxysporum . From this study we can conclude that the pulp and especially the leaves of T.indica could be a promising antifungal agent and the result confirms the use of this plant in traditional medicine for the treatment of fungal infections. Key word: Tamarindus indica, LD50, acute oral toxicity studies, pulp.
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