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Conducting Polymer-Based Multilayer Films for Instructive Biomaterial Coatings

2015; Future Science Ltd; Volume: 1; Issue: 4 Linguagem: Inglês

10.4155/fso.15.79

2056-5623

John G. Hardy, Hetian Li, Jacqueline K. Chow, Sydney A. Geissler, Austin McElroy, Lindsey Nguy, Derek S. Hernandez, Christine E. Schmidt,

Conducting polymers and applications

Aim: To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment. Materials & methods: Thin conducting composite biomaterials based on multilayer films of poly(3.4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared in a layer-by-layer fashion. Fibroblasts were observed with fluorescence microscopy and their alignment (relative to the dipping direction and direction of electrical current passed through the films) was determined using ImageJ. Results: Fibroblasts adhered to and proliferated on the films. Fibroblasts aligned with the dipping direction used during film preparation and this was enhanced by a DC current. Conclusion: We report the preparation of conducting polymer-based films that enhance the alignment of fibroblasts on their surface which is an important feature of a variety of tissues.