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Sarcopenia Does Not Affect Survival or Outcomes in Soft-Tissue Sarcoma

2015; Hindawi Publishing Corporation; Volume: 2015; Linguagem: Inglês

10.1155/2015/146481

1369-1643

Robert J. Wilson, Vignesh K. Alamanda, Katherine G. Hartley, Nathan W. Mesko, Jennifer L. Halpern, Herbert S. Schwartz, Ginger E. Holt,

Mesenchymal stem cell research

Background and Objective . Sarcopenia is associated with decreased survival and increased complications in carcinoma patients. We hypothesized that sarcopenic soft-tissue sarcoma (STS) patients would have decreased survival, increased incidence of wound complications, and increased length of postresection hospital stay (LOS). Methods . A retrospective, single-center review of 137 patients treated surgically for STS was conducted. Sarcopenia was assessed by measuring the cross-sectional area of bilateral psoas muscles (total psoas muscle area, TPA) at the level of the third lumbar vertebrae on a pretreatment axial computed tomography scan. TPA was then adjusted for height (cm 2 /m 2 ). The association between height-adjusted TPA and survival was assessed using Cox proportional hazard model. A logistical model was used to assess the association between height-adjusted TPA and wound complications. A linear model was used to assess the association between height-adjusted TPA and LOS. Results . Height-adjusted TPA was not an independent predictor of overall survival ( p = 0.746 ). Patient age ( p = 0.02 ) and tumor size ( p = 0.009 ) and grade ( p = 0.001 ) were independent predictors of overall survival. Height-adjusted TPA was not a predictor of increased hospital LOS ( p = 0.66 ), greater incidence of postoperative infection ( p = 0.56 ), or other wound complications ( p = 0.14 ). Conclusions . Sarcopenia does not appear to impact overall survival, LOS, or wound complications in patients with STS.