Sumatriptan: A Receptor-Targeted Treatment for Migraine
1993; Annual Reviews; Volume: 44; Issue: 1 Linguagem: Inglês
10.1146/annurev.med.44.1.145
ISSN1545-326X
Autores Tópico(s)Trigeminal Neuralgia and Treatments
Resumosubtypes, neurogenic inflammation ABSTRACT Sumatriptan, recently introduced for the treatment of migraine, heralds the beginning of a molecular era in the pharmacological treatment of migraine headache. An indole (non-ergot alkaloid) derivative with agonist properties at a receptor resembling the 5-HTlD subtype (so-called 5-HT J- like receptor), J sumatriptan is the first antimigraine medication to exhibit receptor-selecti ve properties. Clinical data indicate that sumatriptan relieves headache, nausea, and photophobia in a majority of acute migraine patients, and it possesses favorable side effect and safety profiles. Of great importance, sumatriptan acts through a novel mechanism that we now know is shared by dihydroergotamin e and other useful compounds for the treatment of acute migraine headaches. In this summary, we briefly review the drug's mechanism of action and the emerging clinical experience with its use.
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