A Feline Dental Tumor Resembling Calcifying Epithelial Odontogenic Tumor in Man
1985; SAGE Publishing; Volume: 22; Issue: 5 Linguagem: Inglês
10.1177/030098588502200511
ISSN1544-2217
AutoresJ. H. Vos, S. A. Goedegebuure, G. M. Bron-Dietz,
Tópico(s)Veterinary Oncology Research
ResumoA nine-year-old neutered European shorthair tomcat was presented with a firm, painless, nodular mass of approximately 1 cm diameter around the mandibular incisors. The mass had been noticed a month previously. The cat had no clinical signs. A radiograph showed soft tissue swelling without involvement of bony structures and without dislocation of the incisors. A biopsy of the lesion consisted of cellular connective tissue stroma covered by a parakeratinized stratified squamous epithelium. In the stroma, clusters and cords of polyhedral epithelial cells were present with granular, eosinophilic cytoplasm and distinct cell borders (fig. I). Some of the epithelial cells had intercellular bridges. The nuclei vaned moderately in size and shape and had one, or sometimes two nucleoli. Occasionally cells with two or more nuclei were found. Mitotic figures were rare. Some epithelial cells had intracytoplasmic vacuolization (fig. 2). In a few cell clusters, acellular, amorphous, pale eosinophilic material could be seen between the neoplastic cells with local rounded calcification (fig. 3). This material stained yellow in van Gieson’s, and with Congo red staining the substance had green birefringence in polarized light. The diagnosis of calcifying epithelial odontogenic tumor was made because of the characteristic features: sheets and nests of polyhedral epithelial cells with intercellular bridges; the presence of amorphous amyloid-like material: and calcifying deposits in degenerated neoplastic cells. Since it seemed impossible to remove the
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