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A novel bioadhesive polymer: grafting of tamarind seed polysaccharide andevaluation of its use in buccal delivery of metoprolol succinate

2012; Volume: 4; Issue: 2 Linguagem: Inglês

0975-5071

T Shailaja, K Latha, P Sasibhushan, A M Alkabab, M U Uhumwangho,

Drug Solubulity and Delivery Systems

Tamarind seed polysaccharide (TS) is derived from the kernel powder of seeds of Tamarindus indica lin n.. TS has various pharmaceutical applications, however its ap plication is limited due to uncontrolled rate of hy dration, drop in viscosity on storage and susceptibility to micro bial contamination. Keeping this in view an attempt was made to overcome some of the disadvantages by suitably graf ting the TS with methyl methacrylate (MMA). Chemica l method of grafting by potassium per sulphate and ascorbic acid redox pair was selected for grafting. Taguchi L9 design was applied to optimize the grafting process. The graft ed product was subjected to physical, chemical and spectral analysis. The physical characterization reveals no drop of viscosity on storage, controlled rate of hy dration of Grafted tamarind seed polysaccharide (GTS). The che mical and spectral characterization confirmed the g procedure. Metoprolol succinate a low bioavailable (40-50%) drug was selected for the present study an d buccal patches were formulated using TS and GTS as polymer s. Central composite design was applied to find out the relationship between percentage of TS/GTS and drug release characteristics and to optimize buccal patc hes with 12 hour drug release. The 2% of TS and 2.86% of GTS bu ccal patches were able to show a sustain drug relea se for 12 hours. Invitro, exvivo drug release studies, releas e kinetics, physical parameter studies for all opti mized patch formulations reflect the ideal characteristics of b uccal patch for delivery of metoprolol succinate.