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Homing of Cells from the Bursa of Fabricius to Germinal Centers in the Chicken Spleen

1971; Springer Nature; Linguagem: Inglês

10.1007/978-1-4615-9011-8_17

2214-8019

Helen G. Durkin, Gail A. Theis, G. J. Thorbecke,

Animal Virus Infections Studies

The ability of the chicken to produce humoral immune responses is dependent upon the presence, during ontogeny, of the bursa of Fabricius (1,2), Presence of the other central lymphoid organ, the thymus, is necessary for development of delayed hypersensitivity and of the ability to reject homografts (1,2). It also has been noted that adult chickens, hormonally or surgically bursectomized in ovo, may be completely agammaglobulinemic (3,4) and lack both plasma cells and germinal centers in their lymphoid tissues (5). In addition, inoculation of chickens with avian lymphoid leukosis virus causes initial lesions in bursa follicles, followed by the appearance of enlarged,abnormal germinal centers in the spleen (6). This evidence suggests that the bursa produces precursor cells for the germinal center and plasma cell series of differentiation, as is also supported by the fact that bursa cells are able to produce immunoglobulins earlier than spleen cells during embryogenes is (7).