Hormone Receptor Site Maturation in the Secondary Sex Organs of Immature Male and Female Rats
1976; Arkansas Academy of Science; Volume: 30; Issue: 1 Linguagem: Inglês
ISSN
2326-0505
Autores Tópico(s)Sperm and Testicular Function
ResumoThe effect of a combined dose of pregnant mares' serum (PAAS) and human chor ionic gonadotropin (HCG) on male and female rats 2-25 days old was studied. Groups of animals were given injections for three days, then sacrificed on the fourth day. All injections were begun on the 2nd, 7th, 12th, 17th, and 22ndday of life. Ovaries, uteri, seminal vesicles (SV), and ventral prostate (VP) were removed, dissected free of fat, and weighed. Because uterine weight increased earlier than either SVor VP weight, the ability of the uterus to respond to exogenous estradiol and of the SVand VP to respond to exogenous testosterone was examined. The injection schedule, age groups, and day of sacrifice were the same as above. The uterine response to estrogen was found to appear earlier than the VP-SV response to testosterone. The observations suggest that the receptor sites for estrogen may mature earlier than the receptor sites for testosterone.
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