Artigo Revisado por pares

Laboratory investigation of human deaths from vampire bat rabies in Peru.

1999; American Society of Tropical Medicine and Hygiene; Volume: 60; Issue: 3 Linguagem: Inglês

10.4269/ajtmh.1999.60.502

ISSN

1476-1645

Autores

Cynthia K. Warner, Sherif R. Zaki, Wun‐Ju Shieh, Sylvia G. Whitfield, J S Smith, Lillian A. Orciari, John H. Shaddock, Michael Niezgoda, Colin W. Wright, Cynthia S. Goldsmith, Dane W. Sanderlin, Pamela A. Yager, Charles E. Rupprecht,

Tópico(s)

Viral Infections and Outbreaks Research

Resumo

In the spring of 1996, multiple cases of an acute febrile illness resulting in several deaths in remote locations in Peru were reported to the Centers for Disease Control and Prevention (CDC). The clinical syndromes for these cases included dysphagia and encephalitis. Because bat bites were a common occurrence in the affected areas, the initial clinical diagnosis was rabies. However, rabies was discounted primarily because of reported patient recovery. Samples of brain tissue from two of the fatal cases were received at CDC for laboratory confirmation of the rabies diagnosis. An extensive array of tests on the formalin-fixed tissues confirmed the presence of both rabies viral antigen and nucleic acid. The virus was shown to be most closely related to a vampire bat rabies isolate. These results indicate the importance of maintaining rabies in the differential diagnosis of acute febrile encephalitis, particularly in areas where exposure to vampire bats may occur.

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