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Grunge, related to human Atrophin-like proteins, has multiple functions in Drosophila development

2002; The Company of Biologists; Volume: 129; Issue: 5 Linguagem: Inglês

10.1242/dev.129.5.1119

1477-9129

Alfrun Erkner, Agnès Roure, Bernard Charroux, Michèle Delaage, Nicholas Holway, Nathalie Coré, Christine Vola, Corinne Angelats, Françoise Pagès, Laurent Fasano, Stephen Kerridge,

Cancer-related gene regulation

We have carried out a genetic screen designed to isolate regulators of teashirt expression. One of these regulators is the Grunge gene, which encodes a protein with motifs found in human arginine-glutamic acid dipeptide repeat, Metastasis-associated-like and Atrophin-1 proteins. Grunge is the only Atrophin-like protein in Drosophila, whereas several exist in humans. We provide evidence that Grunge is required for the proper regulation of teashirt but also has multiple activities in fly development. First, Grunge is crucial for correct segmentation during embryogenesis via a failure in the repression of at least four segmentation genes known to regulate teashirt. Second, Grunge acts positively to regulate teashirt expression in proximoventral parts of the leg. Grunge has other regulatory functions in the leg, including the patterning of ventral parts along the entire proximodistal axis and the proper spacing of bristles in all regions.