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BIBTEX RIS

Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis

2015; Oxford University Press; Volume: 107; Issue: 9 Linguagem: Inglês

10.1093/jnci/djv178

ISSN

1460-2105

Autores

Kevin T. Nead, Stephen J. Sharp, Deborah J. Thompson, Jodie N. Painter, David B. Savage, Robert K. Semple, Adam Barker, John R. B. Perry, John Attia, Alison M. Dunning, Douglas F. Easton, Elizabeth Holliday, Luca A. Lotta, Tracy A. O’Mara, Mark McEvoy, Paul D.P. Pharoah, Rodney J. Scott, Amanda B. Spurdle, Claudia Langenberg, Nicholas J. Wareham, Robert A. Scott,

Tópico(s)

Cancer-related molecular mechanisms research

Resumo

Background:Insulinemia and type 2 diabetes (T2D) have been associated with endometrial cancer risk in numerous observational studies. However, the causality of these associations is uncertain. Here we use a Mendelian randomization (MR) approach to assess whether insulinemia and T2D are causally associated with endometrial cancer.

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