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Cancer immunotherapy targeting neoantigens

2015; Elsevier BV; Volume: 28; Issue: 1 Linguagem: Inglês

10.1016/j.smim.2015.11.002

1096-3618

Yong‐Chen Lu, Paul F. Robbins,

Monoclonal and Polyclonal Antibodies Research

Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunotherapy. Here we review the discoveries of neoantigens in the past two decades and the current advances in neoantigen identification. We also discuss the potential benefits and obstacles to the development of effective cancer immunotherapies targeting neoantigens.