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Avaliação dos níveis salivares de interleucina-1b (IL-1b) em relação ao status periodontal em fumantes e não-fumantes

2016; Editora da Pontifícia Universidade Católica do Rio Grande do Sul (EDIPUCRS); Volume: 30; Issue: 4 Linguagem: Inglês

10.15448/1980-6523.2015.4.15204

1980-6523

Shokhan Hama Ali, Mustafa Jamel Abdullah, Shanaz Mohammad Gaphor,

Oral Health Pathology and Treatment

Normal 0 false false false MicrosoftInternetExplorer4 Objective: To evaluate the effect of smoking on periodontal disease and the relationship between salivary IL-1b (IL-1b) and clinical periodontal signs and to investigate salivary interleukine-1b as a biomarker for diagnosis of periodontal disease severity. Material and Methods: The sample comprised 80 male volunteers (40 smokers and 40 nonsmokers); aged 25-40 years old. Personal information was obtained from all subjects. Three indices were applied to measure the periodontal condition including plaque index, bleeding index and clinical attachment level. The assay for IL-1b was performed by enzyme-linked immunosorbent assay. Chi square test, T-test and analysis of variance (ANOVA) were used to analyze the data. Results: Among subjects with periodontitis, the mean value of plaque index was higher in smokers (1.87) (P≥0.05); the mean value of clinical attachment level and bone loss reported were significantly higher among smokers (3 and 2.7 respectively) (P≤0.05 and P=0.04, respectively), while the mean value of bleeding index was higher among non-smokers (0.22) (P=0.000). The mean value of IL-1b was higher among smokers and non-smokers with periodontitis (526 pg/ml and 357 pg/ml, respectively) than the groups of smokers and non smokers healthy subjects (124 pg/ml and 82 pg/ml, respectively); (P value=0.000). The correlation between salivary IL-1b levels and plaque index, bleeding on probing, clinical attachment level, and bone loss was significant (correlation P<0.001). Conclusions: A positive association was observed between periodontal diseas and smoking, salivary IL-1b levels were positively associated with clinical signs of periodontal disease, and it appears to serve as biomarker of periodontitis. /* Style Definitions */ table.MsoNormalTable {mso-style-name:Table Normal; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:Times New Roman; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;}