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The role of oxidative stress in atherosclerosis.

2009; National Institutes of Health; Volume: 50; Issue: 5 Linguagem: Inglês

Georgia Vogiatzi, Dimitris Tousoulis, Christodoulos Stefanadis,

Atherosclerosis and Cardiovascular Diseases

According to the theory of ox-idative stress, atherosclerosis is the resultof the oxidative modification of low densi-ty lipoproteins (LDL) in the arterial wallby reactive oxygen species (ROS). Evidencesuggests that common risk factors for ath-erosclerosis increase the risk of the pro-duction of free ROS, not only from theendothelial cells, but also from the smoothmuscle cells and the adventitial cells.