Portal de Periódicos da CAPES

Comparison of the metabolism of cholesterol, cholestanol, and β-sitosterol in L-cell mouse fibroblasts

1971; Elsevier BV; Volume: 12; Issue: 6 Linguagem: Inglês

10.1016/s0022-2275(20)39452-9

1539-7262

George H. Rothblat, Christina H. Burns,

Chemokine receptors and signaling

The following data have been obtained from comparative studies on the metabolism of cholesterol, cholestanol, and @-sitosterol by L-cell mouse fibroblasts.(7) When the sterols are added to the growth medium under similar conditions, cellular incorporation of cholesterol > cholestanol > @-sitosterol; (2) only limited cellular esterification of these compounds occurs; (3) no metabolic products arising from the sterols could be detected; (4) influx of all sterols is dependent upon the concentration ; and (5) exogenous cholesterol reduces mevalonate incorporation into cellular sterol to a lesser extent than acetate or glucose.The metabolism of these sterols is discussed in relation to their ability to influence de novo sterol biosynthesis.