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Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

2015; American Association for the Advancement of Science; Volume: 350; Issue: 6258 Linguagem: Inglês

10.1126/science.aad0616

1095-9203

Hye‐Jung Kim, R. Anthony Barnitz, Taras Kreslavsky, Flavian D. Brown, Howell Moffett, Madeleine E. Lemieux, Yasemin Kaygusuz, Torsten Meißner, Tobias A.W. Holderried, Susan Chan, Philippe Kastner, W. Nicholas Haining, Harvey Cantor,

CAR-T cell therapy research

How T cells maintain their identity Although best known for their pathogen-fighting prowess, T lymphocytes also ensure that the immune response does not run amok. A subset of T cells called regulatory T cells (T regs ) performs this function by, for example, making sure T cells only attack pathogens and not self. T cells can exhibit plasticity in their functions in the face of an inflammatory stimulus. Kim et al. sought to identify the molecules that ensure the stable maintenance of T regs . Using genetically modified mice, they found that both CD4 + and CD8 + T regs require the transcription factor Helios to stably maintain their identity. Science , this issue p. 334