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Manool, a Salvia officinalis diterpene, induces selective cytotoxicity in cancer cells

2015; Springer Science+Business Media; Volume: 68; Issue: 5 Linguagem: Inglês

10.1007/s10616-015-9927-0

1573-0778

Pollyanna Francielli de Oliveira, Carla Carolina Munari, Heloiza Diniz Nicolella, Rodrigo Cássio Sola Veneziani, Denise Crispim Tavares,

Ginger and Zingiberaceae research

Manool, a diterpene isolated from Salvia officinalis, was evaluated by the XTT colorimetric assay for cytotoxicity and selectivity against different cancer cell lines: B16F10 (murine melanoma), MCF-7 (human breast adenocarcinoma), HeLa (human cervical adenocarcinoma), HepG2 (human hepatocellular carcinoma), and MO59J, U343 and U251 (human glioblastoma). A normal cell line (V79, Chinese hamster lung fibroblasts) was used to compare the selectivity of the test substance. Manool exhibited higher cytotoxic activity against HeLa (IC50 = 6.7 ± 1.1 µg/mL) and U343 (IC50 = 6.7 ± 1.2 µg/mL) cells. In addition, in the used experimental protocols, the treatment with manool was significantly more cytotoxic for different tumor cell lines than for the normal cell line V79 (IC50 = 49.3 ± 3.3 µg/mL), and showed high selectivity. These results suggest that manool may be used to treat cancer without affecting normal cells.