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Fotoféresis en el tratamiento de Síndrome de Sézary: Caso clínico

2015; Q16635223; Volume: 143; Issue: 11 Linguagem: Inglês

10.4067/s0034-98872015001100011

0717-6163

Montserrat Molgó, Alejandra Jaque, Verónica Vial, Mauricio Ocqueteau, Jaime Pereira, Mayling Chang, Sergio González,

CAR-T cell therapy research

Sézary syndrome treated with extracorporeal photopheresis. Report of one caseSézary syndrome (SS) is an unusually aggressive T-cell lymphoma characterized by the triad of erythroderma, the presence of more than 1,000 Sézary cells in peripheral blood and lymphadenopathies.It is accompanied by generalized pruritus and poor quality of life.The management of SS depends on its stage, patient comorbidities, and treatment availability.Extracorporeal photopheresis (ECP) is the first line of treatment for patients with T-cell lymphomas in stage IVA1, IVA2 or SS.This treatment comprises three phases: leukapheresis, photoactivation and subsequent reinfusion of lymphocytes.As it is an immunomodulatory therapy it does not produce generalized immunosuppression.We report a 76 year-old male with SS stage IIIb initially treated with 12 sessions of ultraviolet phototherapy without response.After 10 well-tolerated sessions of ECP, itching and skin lesions eventually disappeared.