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Different immune cells mediate mechanical pain hypersensitivity in male and female mice

2015; Nature Portfolio; Volume: 18; Issue: 8 Linguagem: Inglês

10.1038/nn.4053

1546-1726

Robert E. Sorge, Josiane C.S. Mapplebeck, Sarah F. Rosen, Simon Beggs, Sarah Taves, Jessica K. Alexander, Loren J. Martin, Jean‐Sebastien Austin, Susana G. Sotocinal, Di Chen, Mu Yang, Xiang Shi, Hao Huang, Nicolas J. Pillon, Philip J. Bilan, YuShan Tu, Amira Klip, Ru‐Rong Ji, Ji Zhang, Michael W. Salter, Jeffrey S. Mogil,

Neuroinflammation and Neurodegeneration Mechanisms

A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.