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Solubility of rosuvastatin calcium in different neat solvents at different temperatures

2015; Elsevier BV; Volume: 94; Linguagem: Inglês

10.1016/j.jct.2015.11.019

1096-3626

Doaa Hasan Alshora, Nazrul Haq, Fars K. Alanazi, Mohamed Abbas Ibrahim, Faiyaz Shakeel,

Analytical Methods in Pharmaceuticals

In the current research work, the solubility of rosuvastatin calcium (ROSCa) in seven different neat solvents such as water, ethanol, 1-butanol, 2-butanol, ethylene glycol (EG), isopropyl alcohol (IPA) and propane-1,2-diol (PG) was measured at five different temperatures i.e. T = (298.15 to 318.15) K and atmospheric pressure. Values of the experimental solubility of ROSCa were correlated with Apelblat and ideal models which showed good correlation and model fitting. The solubility (as mole fraction) of ROSCa was recorded highest in PG (1.89 · 10−2 at T = 318.15 K) followed by 1-butanol (8.20 · 10−4 at T = 318.15 K), ethanol (6.81 · 10−4 at T = 318.15 K), IPA (5.66 · 10−4 at T = 318.15 K), EG (5.03 · 10−4 at T = 318.15 K), 2-butanol (1.08 · 10−4 at T = 318.15 K) and water (1.40 · 10−5 at T = 318.15 K). The experimental results from this research work would be helpful in the development of conventional and advanced liquid dosage forms of ROSCa.