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Cholecystokinin Induced Gallbladder Contraction is Influenced by Nicotinic and Muscarinic Receptors

1989; Taylor & Francis; Volume: 97; Issue: 5 Linguagem: Inglês

10.3109/13813458909104553

0003-9799

Marı́a J. Pozo, Ginés M. Salido, Juan Antonio Madrid,

Anesthesia and Pain Management

AbstractEffects of pirenzepine, known as a muscarinic receptor antagonist, on the contraction of dog gallbladder elicited by cholecystokinin (CCK) were examined in comparison with atropine and hexamethonium ones. Intraluminal gallbladder pressure in an in situ anaesthetized dog model was chosen for studying gallbladder motility. The intravenous administration of pirenzepine (0.75 mg/kg b.wt.), atropine (3 mg/kg b.wt.) or hexamethonium (5 mg/kg b.wt.) elicited a marked decrease in the increase of intraluminal gallbladder pressure induced by intravenous bolus injections of CCK (0.25-2 Ivy dog unit/kg b.wt.) and by continuous infusion of CCK (0.025-0.4 Ivy dog unit/kg b.wt./min). It was concluded that CCK induced gallbladder contractions were influenced by both nicotinic and muscarinic receptors.