Folic Acid Deficiency in the Lamb
1952; Elsevier BV; Volume: 46; Issue: 1 Linguagem: Inglês
10.1093/jn/46.1.123
ISSN1541-6100
AutoresH. H. Draper, B. Connor Johnson,
Tópico(s)Peroxisome Proliferator-Activated Receptors
ResumoA series of newborn lambs maintained on a “synthetic milk” diet deficient in folic acid developed a syndrome characterized by leukopenia and diarrhea, followed in most cases by pneumonia and death. White cell regeneration was induced by the administration of folic acid but no detectable response was obtained for formyl folic acid. “X-methyl” folic acid was effective as an antimetabolite when administered early in the experimental period and 4-amino folic acid produced a rapid depression in leukocyte levels, followed by a gradual regeneration which occurred in spite of increased doses of the antivitamin. The “citrovorum factor” was effective in reversing the depressive effect of aminopterin on white cell levels in the blood. Megaloblastic cells were absent from the bone marrow of folic acid-deficient animals. The results obtained demonstrate that folic acid is an essential nutrient for the lamb.
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