Portal de Periódicos da CAPES

Fanconi Syndrome in Irish Wolfhound Siblings

2018; American Animal Hospital Association; Volume: 54; Issue: 3 Linguagem: Inglês

10.5326/jaaha-ms-6439

1547-3317

Nick Bommer, Serena E. Brownlie, L. Morrison, Marge Chandler, J. W. Simpson,

Metabolism and Genetic Disorders

Three juvenile male Irish wolfhound littermates presented with marked polyuria and polydipsia. The four female siblings were apparently unaffected. Diagnostic testing revealed glucosuria with normoglycemia, generalized aminoaciduria, hypokalemia and metabolic acidosis consistent with Fanconi syndrome. Renal ultrasonographic and histologic findings are presented. Cases were managed with a supplementation regimen based on a treatment protocol for Fanconi syndrome in basenjis. These dogs did not have angular limb deformities as documented previously in juvenile canine siblings with Fanconi syndrome. Fanconi syndrome has not been previously described in Irish wolfhound siblings.