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Parkinsonism in adult-onset Rasmussens's encephalitis: a clinical picture presenting as corticobasal syndrome

2015; Taylor & Francis; Volume: 126; Issue: 12 Linguagem: Inglês

10.3109/00207454.2015.1135438

1563-5279

Leonilda Bilo, Silvio Peluso, Antonella Antenora, Anna De Rosa, Marcello Esposito, Stefano Barbato, Sabina Pappatà, Giuseppe De Michele,

Neuroscience and Neuropharmacology Research

Rasmussen's encephalitis (RE) is an immune-mediated disease, typically affecting a single cerebral hemisphere. Intractable epilepsy, hemiplegia and cognitive decline represent the clinical features; movement disorders have rarely been described. We report a case of adult-onset RE which developed hemiparkinsonism after an extraordinarily long prodromal period; to date, this is the first description of parkinsonism in RE. The association between cortical symptoms and extrapyramidal features evokes a clinical suspect of corticobasal syndrome (CBS); our patient satisfies the diagnostic criteria for possible CBS. Clinical and neuro-radiological reasons might further explain why RE accompanied by extrapyramidal signs may present as a CBS.