Redox chemistry of cobalamin and its derivatives
2015; Elsevier BV; Volume: 309; Linguagem: Inglês
10.1016/j.ccr.2015.11.001
ISSN1873-3840
AutoresIlia А. Dereven’kov, Denis S. Salnikov, Radu Silaghi‐Dumitrescu, Sergei V. Makarov, O. I. Koifman,
Tópico(s)Heme Oxygenase-1 and Carbon Monoxide
ResumoA comprehensive review on redox reactions of Co(III), Co(II) and Co(I) forms of cobalamins (vitamin B12) and their derivatives (cobinamide, cobyrinates) is presented. An influence of coordination environment of cobalt ion on reactivity of corresponding species is discussed. Mechanisms of reduction of Co(III) and Co(II) species as well as oxidation of Co(II) and Co(I) complexes are given in terms of their in vivo and catalytic implications.
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