Produção Nacional
Revisado por pares
Lymph node micrometastases in initial stage cervical cancer and tumoral recurrence
2015; Elsevier BV; Volume: 133; Issue: 1 Linguagem: Inglês
10.1016/j.ijgo.2015.08.019
ISSN1879-3479
AutoresLeandro F. Colturato, Roney César Signorini Filho, Raquel Civolani Marques Fernandes, Luíz Henrique Gebrim, Antônio Hélio Oliani,
Tópico(s)Uterine Myomas and Treatments
ResumoObjective To evaluate the prevalence of micrometastases in lymph node tissue of patients with stage Ib1–IIA cervical cancer, the correlation of micrometastases with tumor recurrence and survival, and the expression of D2-40 in the primary tumor of patients with recurrence and/or micrometastases and its correlation with histopathologic findings. Methods In a retrospective study, the medical records of all patients with cervical cancer treated at a hospital in São Paulo, Brazil, between 2001 and 2007 were reviewed. Patients with no lymph node metastases and treated with radical hysterectomy without adjuvant treatment were included. Tumor sections were reviewed and lymph nodes were analyzed with AE1/AE3. Patients with and without recurrence were compared. The presence of lymph node micrometastasis or isolated tumor cells was also evaluated. Results Of the 83 patients evaluated, 15 (18%) had recurrence. Significant differences between patients with and without recurrence were observed with regard to tumor greatest axis, clinical stage, number of micrometastases, and negative lymph nodes (P ≤ 0.04). Lymph node micrometastases and isolated tumor cells were significantly different for a stromal invasion depth greater than 2/3 (P = 0.046). Conclusion The presence of lymph node micrometastases is an important risk factor for tumor recurrence. These patients should be considered eligible for adjuvant radiochemotherapy treatment.
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