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Kinetic Characterization of Dopamine as a Suicide Substrate of Tyrosinase

1987; Volume: 2; Issue: 1 Linguagem: Inglês

10.3109/14756368709030356

8755-5093

José Tudela, Francisco Garcı́a-Cánovas, R. Varón, Mercedes Jiménez, Francisco Garcı́a-Carmona, José Antonio Lozano,

Computational Drug Discovery Methods

A kinetic study of the inactivation of frog epidermis tyrosinase by a suicide substrate dopamine hydrochloride is described. The kinetic parameters and constants which characterize this reaction have been determined and the effects of pH and the stoichiometric inhibition by chloride have been considered.