Heterogenity of γ-Globulins
1963; Elsevier BV; Linguagem: Inglês
10.1016/s0065-2776(08)60111-x
ISSN1557-8445
Autores Tópico(s)Hemoglobinopathies and Related Disorders
ResumoThis chapter gives a detailed physicochemical and immunologic characterization of the four classes of globulins in normal and neoplastic plasma cells. Unique characteristics of the γ-globulins are their antibody activity and an extensive heterogeneity not seen in other serum proteins. Heterogeneity is characteristic of each class of γ-globulins with respect to electrophoretic mobility, antibody activity, hexose content, antigenic determinants, and genetic properties. The serum γ -globulins in many species are now known to include three major groups of proteins (γ, β2A, γ1M). A fourth group, the γ-microglobulins may be formed in normal, as well as in malignant plasmacytes and related cells. A dual relationship exists among these groups of proteins. Studies at the submolecular level of the interrelationships among different γ-globulin groups, among different γ-globulin molecules, and among different γ-globulin functions and a better understanding of the physicochemical and immunological heterogeneity of the γ-globulins is beginning to develop. This rapidly moving area of investigation, taking advantage of developments in other fields, is, in turn, contributing to advancement in many areas of immunology and other biological science.
Referência(s)